Novel piperine-carboximidamide hybrids: design, synthesis, and antiproliferative activity via a multi-targeted inhibitory pathway

A new series of piperine-carboximidamide hybrids VIa-k was developed as a new cytotoxic agent targeting EGFR, BRAF, and CDK2. The antiproliferative effect against four cancer cells was investigated against erlotinib. Hybrids VIc, VIf, VIg, VIi, and VIk have the highest antiproliferative activity. Co...

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Detalles Bibliográficos
Autores principales: Al-Wahaibi, Lamya H., Mahmoud, Mohamed A., Mostafa, Yaser A., Raslan, Ali E., Youssif, Bahaa G. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9721426/
https://www.ncbi.nlm.nih.gov/pubmed/36453023
http://dx.doi.org/10.1080/14756366.2022.2151593

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9721426/
https://www.ncbi.nlm.nih.gov/pubmed/36453023
http://dx.doi.org/10.1080/14756366.2022.2151593

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