Cargando…

Novel piperine-carboximidamide hybrids: design, synthesis, and antiproliferative activity via a multi-targeted inhibitory pathway

A new series of piperine-carboximidamide hybrids VIa-k was developed as a new cytotoxic agent targeting EGFR, BRAF, and CDK2. The antiproliferative effect against four cancer cells was investigated against erlotinib. Hybrids VIc, VIf, VIg, VIi, and VIk have the highest antiproliferative activity. Co...

Descripción completa

Detalles Bibliográficos
Autores principales:	Al-Wahaibi, Lamya H., Mahmoud, Mohamed A., Mostafa, Yaser A., Raslan, Ali E., Youssif, Bahaa G. M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2022
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9721426/ https://www.ncbi.nlm.nih.gov/pubmed/36453023 http://dx.doi.org/10.1080/14756366.2022.2151593

Ejemplares similares

Design, Synthesis, and Biological Evaluation of Indole-2-carboxamides as Potential Multi-Target Antiproliferative Agents
por: Al-Wahaibi, Lamya H., et al.
Publicado: (2023)

Synthesis and Biological Evaluation of Indole-2-Carboxamides with Potent Apoptotic Antiproliferative Activity as EGFR/CDK2 Dual Inhibitors
por: Al-Wahaibi, Lamya H., et al.
Publicado: (2022)

Design, Synthesis, and Biological Evaluation of Novel 3-Cyanopyridone/Pyrazoline Hybrids as Potential Apoptotic Antiproliferative Agents Targeting EGFR/BRAF(V600E) Inhibitory Pathways
por: Al-Wahaibi, Lamya H., et al.
Publicado: (2023)

Structure-based design, synthesis, and biological evaluation of novel piperine–resveratrol hybrids as antiproliferative agents targeting SIRT-2
por: Tantawy, Ahmed H., et al.
Publicado: (2021)

Quinazolin-4-one/3-cyanopyridin-2-one Hybrids as Dual Inhibitors of EGFR and BRAF(V600E): Design, Synthesis, and Antiproliferative Activity
por: Al-Wahaibi, Lamya H., et al.
Publicado: (2023)

One-Pot Synthesis of 1-Thia-4-azaspiro[4.4/5]alkan-3-ones via Schiff Base: Design, Synthesis, and Apoptotic Antiproliferative Properties of Dual EGFR/BRAF(V600E) Inhibitors
por: Al-Wahaibi, Lamya H., et al.
Publicado: (2023)

Design, Synthesis, and Antiproliferative Activity of New 5-Chloro-indole-2-carboxylate and Pyrrolo[3,4-b]indol-3-one Derivatives as Potent Inhibitors of EGFR(T790M)/BRAF(V600E) Pathways
por: Al-Wahaibi, Lamya H., et al.
Publicado: (2023)

Design, Synthesis, Antiproliferative Actions, and DFT Studies of New Bis–Pyrazoline Derivatives as Dual EGFR/BRAF(V600E) Inhibitors
por: Al-Wahaibi, Lamya H., et al.
Publicado: (2023)

Synthesis and Structure Determination of Substituted Thiazole Derivatives as EGFR/BRAF(V600E) Dual Inhibitors Endowed with Antiproliferative Activity
por: Al-Wahaibi, Lamya H., et al.
Publicado: (2023)

Design, synthesis, apoptotic, and antiproliferative effects of 5-chloro-3- (2-methoxyvinyl)-indole-2-carboxamides and pyrido[3,4-b]indol-1-ones as potent EGFR(WT/)EGFR(T790M) inhibitors
por: Al-Wahaibi, Lamya H., et al.
Publicado: (2023)

Design, Synthesis, Biological Evaluation, and Computational Studies of Novel Tri-Aryl Imidazole-Benzene Sulfonamide Hybrids as Promising Selective Carbonic Anhydrase IX and XII Inhibitors
por: Al-Wahaibi, Lamya H., et al.
Publicado: (2021)

New 1,2,3-Triazole/1,2,4-triazole Hybrids as Aromatase Inhibitors: Design, Synthesis, and Apoptotic Antiproliferative Activity
por: Maghraby, Mohamed T-E, et al.
Publicado: (2023)

Piperidine-1-carboximidamide
por: Tiritiris, Ioannis
Publicado: (2012)

Design, Synthesis, and Antibacterial Screening of Some Novel Heteroaryl-Based Ciprofloxacin Derivatives as DNA Gyrase and Topoisomerase IV Inhibitors
por: Al-Wahaibi, Lamya H., et al.
Publicado: (2021)

Pyridine-4-carboximidamidate chloride
por: Fan, Ping, et al.
Publicado: (2009)

Synthesis of novel amidines via one-pot three component reactions: Selective topoisomerase I inhibitors with antiproliferative properties
por: El-Sheref, Essmat M., et al.
Publicado: (2022)

Design and synthesis of new thiazolidinone/uracil derivatives as antiproliferative agents targeting EGFR and/or BRAF(V600E)
por: Alshammari, Mohammed B., et al.
Publicado: (2022)

Synthesis, structure, and biological activity of novel heterocyclic sulfonyl-carboximidamides
por: Gobis, Katarzyna, et al.
Publicado: (2013)

Pyridine-2-carboximidamidate chloride monohydrate
por: Chen, Qifan, et al.
Publicado: (2010)

Synthesis, structure, and antimicrobial activity of heterocyclic phenylsulfonyl- and 4-aminophenylsulfonyl-carboximidamides
por: Gobis, Katarzyna, et al.
Publicado: (2012)

N′-Hydroxypyridine-2-carboximidamide
por: Suchetan, P. A., et al.
Publicado: (2013)

N-(2-Pyridylmethanimidamido)pyridine-2-carboximidamide
por: Wang, Yingchun
Publicado: (2010)

Synthesis, Antioxidant and Antiproliferative Actions of 4-(1,2,3-Triazol-1-yl)quinolin-2(1H)-ones as Multi-Target Inhibitors
por: El-Sheref, Essmat M., et al.
Publicado: (2023)

Design, Synthesis, Docking Study, and Antiproliferative Evaluation of Novel Schiff Base–Benzimidazole Hybrids with VEGFR-2 Inhibitory Activity
por: Abd El-Lateef, Hany M., et al.
Publicado: (2023)

Crystal structures of N′-aminopyridine-2-carboximidamide and N′-{[1-(pyridin-2-yl)ethylidene]amino}pyridine-2-carboximidamide
por: Eya’ane Meva, Francois, et al.
Publicado: (2017)

Design, Synthesis, and Antiproliferative Activity of Novel Neocryptolepine–Rhodanine Hybrids
por: El-Bahnsawye, Mohamed, et al.
Publicado: (2022)

Novel chalcone/aryl carboximidamide hybrids as potent anti-inflammatory via inhibition of prostaglandin E2 and inducible NO synthase activities: design, synthesis, molecular docking studies and ADMET prediction
por: Ibrahim, Tarek S., et al.
Publicado: (2021)

Crystal structure of N′-hydroxypyrimidine-2-carboximidamide
por: Jasmine, Nithianantham Jeeva, et al.
Publicado: (2014)

(E)-3-Chloro-N′-hydroxybenzene-1-carboximidamide
por: Sreenivasa, S., et al.
Publicado: (2012)

Discovery of novel oxazole-based macrocycles as anti-coronaviral agents targeting SARS-CoV-2 main protease
por: Al-Wahaibi, Lamya H., et al.
Publicado: (2021)

Design, synthesis, and insecticidal activity evaluation of piperine derivatives
por: Zhang, Chiying, et al.
Publicado: (2022)

Design and Synthesis of (2-oxo-1,2-Dihydroquinolin-4-yl)-1,2,3-triazole Derivatives via Click Reaction: Potential Apoptotic Antiproliferative Agents
por: El-Sheref, Essmat M., et al.
Publicado: (2021)

Synthesis and Characterization of Molecular Imprinting Polymer Microspheres of Piperine: Extraction of Piperine from Spiked Urine
por: Roland, Rachel Marcella, et al.
Publicado: (2016)

N′-Hydroxypyridine-2-carboximidamide–succinic acid (2/1)
por: Liu, Jiyong
Publicado: (2013)

Evaluation of radiofluorinated carboximidamides as potential IDO-targeted PET tracers for cancer imaging
por: Huang, Xuan, et al.
Publicado: (2017)

Adamantane-Isothiourea Hybrid Derivatives: Synthesis, Characterization, In Vitro Antimicrobial, and In Vivo Hypoglycemic Activities
por: Al-Wahaibi, Lamya H., et al.
Publicado: (2017)

Synthesis and In Vitro Antiproliferative Activity of New 1-Phenyl-3-(4-(pyridin-3-yl)phenyl)urea Scaffold-Based Compounds
por: Al-Sanea, Mohammad M., et al.
Publicado: (2018)

Inhibitory effect of piperine on Helicobacter pylori growth and adhesion to gastric adenocarcinoma cells
por: Tharmalingam, Nagendran, et al.
Publicado: (2014)

Isatin-benzoazine molecular hybrids as potential antiproliferative agents: synthesis and in vitro pharmacological profiling
por: Abdel-Aziz, Hatem A, et al.
Publicado: (2017)

Design, Synthesis, and Biological Evaluation of Artemisinin-Indoloquinoline Hybrids as Potent Antiproliferative Agents
por: Wang, Li, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_02q152s1h6a0bai86fg6qpi2cp