Investigation of the enantioselectivity of acetylcholinesterase and butyrylcholinesterase upon inhibition by tacrine-iminosugar heterodimers

The copper-catalysed azide-alkyne cycloaddition was applied to prepare three enantiomeric pairs of heterodimers containing a tacrine residue and a 1,4-dideoxy-1,4-imino-D-arabinitol (DAB) or 1,4-dideoxy-1,4-imino-L-arabinitol (LAB) moiety held together via linkers of variable lengths containing a 1,...

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Detalles Bibliográficos
Autores principales: Vaaland, I. Caroline, López, Óscar, Puerta, Adrián, Fernandes, Miguel X., Padrón, José M., Fernández-Bolaños, José G., Sydnes, Magne O., Lindbäck, Emil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9721440/
https://www.ncbi.nlm.nih.gov/pubmed/36458374
http://dx.doi.org/10.1080/14756366.2022.2150762

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9721440/
https://www.ncbi.nlm.nih.gov/pubmed/36458374
http://dx.doi.org/10.1080/14756366.2022.2150762

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