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The ANC-1 (Nesprin-1/2) organelle-anchoring protein functions through mitochondria to polarize axon growth in response to SLT-1

A family of giant KASH proteins, including C. elegans ANC-1 and mammalian Nesprin-1 and -2, are involved in organelle anchoring and are associated with multiple neurodevelopmental disorders including autism, bipolar disorder, and schizophrenia. However, little is known about how these proteins funct...

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Detalles Bibliográficos
Autores principales: Fischer, Nathan C., Friedman, Vladislav, Martinez-Reyes, Miguel A., Hao, Hongyan, Chowdhury, Tamjid A., Starr, Daniel A., Quinn, Christopher C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9721489/
https://www.ncbi.nlm.nih.gov/pubmed/36409768
http://dx.doi.org/10.1371/journal.pgen.1010521