Efficient CRISPR-Cas9-mediated mutagenesis in primary human B cells for identifying plasma cell regulators

Human B lymphocytes are attractive targets for immunotherapies in autoantibody-mediated diseases. Gene editing technologies could provide a powerful tool to determine gene regulatory networks regulating B cell differentiation into plasma cells, and identify novel therapeutic targets for prevention a...

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Detalles Bibliográficos
Autores principales: Le, Tuan Anh, Chu, Van Trung, Lino, Andreia C., Schrezenmeier, Eva, Kressler, Christopher, Hamo, Dania, Rajewsky, Klaus, Dörner, Thomas, Dang, Van Duc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9722396/
https://www.ncbi.nlm.nih.gov/pubmed/36514352
http://dx.doi.org/10.1016/j.omtn.2022.11.016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9722396/
https://www.ncbi.nlm.nih.gov/pubmed/36514352
http://dx.doi.org/10.1016/j.omtn.2022.11.016

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