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Alterations in rat prefrontal cortex kynurenic acid levels are involved in the enduring cognitive dysfunctions induced by tetrahydrocannabinol exposure during the adolescence

INTRODUCTION: Cannabis abuse during adolescence is a risk factor for cognitive impairments in psychiatric disorders later in life. To date, the possible causal relationship between cannabinoids, kynurenic acid (KYNA; i.e., a neuroactive metabolite of tryptophan degradation) and cognition has not bee...

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Detalles Bibliográficos
Autores principales: Beggiato, Sarah, Ieraci, Alessandro, Zuccarini, Mariachiara, Di Iorio, Patrizia, Schwarcz, Robert, Ferraro, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9722723/
https://www.ncbi.nlm.nih.gov/pubmed/36483135
http://dx.doi.org/10.3389/fpsyt.2022.996406