Cannabinoid non-cannabidiol site modulation of TRPV2 structure and function

TRPV2 is a ligand-operated temperature sensor with poorly defined pharmacology. Here, we combine calcium imaging and patch-clamp electrophysiology with cryo-electron microscopy (cryo-EM) to explore how TRPV2 activity is modulated by the phytocannabinoid Δ(9)-tetrahydrocannabiorcol (C16) and by probe...

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Detalles Bibliográficos
Autores principales: Zhang, Liying, Simonsen, Charlotte, Zimova, Lucie, Wang, Kaituo, Moparthi, Lavanya, Gaudet, Rachelle, Ekoff, Maria, Nilsson, Gunnar, Hellmich, Ute A., Vlachova, Viktorie, Gourdon, Pontus, Zygmunt, Peter M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9722916/
https://www.ncbi.nlm.nih.gov/pubmed/36470868
http://dx.doi.org/10.1038/s41467-022-35163-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9722916/
https://www.ncbi.nlm.nih.gov/pubmed/36470868
http://dx.doi.org/10.1038/s41467-022-35163-y

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