Mitochondrial citrate accumulation drives alveolar epithelial cell necroptosis in lipopolysaccharide-induced acute lung injury

Necroptosis is the major cause of death in alveolar epithelial cells (AECs) during acute lung injury (ALI). Here, we report a previously unrecognized mechanism for necroptosis. We found an accumulation of mitochondrial citrate (citrate(mt)) in lipopolysaccharide (LPS)-treated AECs because of the dow...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Hui-Hui, Jiang, Hui-Ling, Tao, Jia-Hao, Zhang, Chen-Yu, Xiong, Jian-Bing, Yang, Jin-Tong, Liu, Yu-Biao, Zhong, Wen-Jing, Guan, Xin-Xin, Duan, Jia-Xi, Zhang, Yan-Feng, Liu, Shao-Kun, Jiang, Jian-Xin, Zhou, Yong, Guan, Cha-Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9722936/
https://www.ncbi.nlm.nih.gov/pubmed/36443565
http://dx.doi.org/10.1038/s12276-022-00889-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9722936/
https://www.ncbi.nlm.nih.gov/pubmed/36443565
http://dx.doi.org/10.1038/s12276-022-00889-8

Ejemplares similares