Cargando…

Mitochondrial citrate accumulation drives alveolar epithelial cell necroptosis in lipopolysaccharide-induced acute lung injury

Necroptosis is the major cause of death in alveolar epithelial cells (AECs) during acute lung injury (ALI). Here, we report a previously unrecognized mechanism for necroptosis. We found an accumulation of mitochondrial citrate (citrate(mt)) in lipopolysaccharide (LPS)-treated AECs because of the dow...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Hui-Hui, Jiang, Hui-Ling, Tao, Jia-Hao, Zhang, Chen-Yu, Xiong, Jian-Bing, Yang, Jin-Tong, Liu, Yu-Biao, Zhong, Wen-Jing, Guan, Xin-Xin, Duan, Jia-Xi, Zhang, Yan-Feng, Liu, Shao-Kun, Jiang, Jian-Xin, Zhou, Yong, Guan, Cha-Xiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9722936/ https://www.ncbi.nlm.nih.gov/pubmed/36443565 http://dx.doi.org/10.1038/s12276-022-00889-8

Ejemplares similares

Mitochondrial citrate accumulation triggers senescence of alveolar epithelial cells contributing to pulmonary fibrosis in mice
por: Hong, Jie-Ru, et al.
Publicado: (2023)

COX-2/sEH Dual Inhibitor PTUPB Attenuates Epithelial-Mesenchymal Transformation of Alveolar Epithelial Cells via Nrf2-Mediated Inhibition of TGF-β1/Smad Signaling
por: Zhang, Chen-Yu, et al.
Publicado: (2022)

TREM-1 triggers necroptosis of macrophages through mTOR-dependent mitochondrial fission during acute lung injury
por: Zhong, Wen-Jing, et al.
Publicado: (2023)

A COX-2/sEH dual inhibitor PTUPB alleviates lipopolysaccharide-induced acute lung injury in mice by inhibiting NLRP3 inflammasome activation
por: Yang, Hui-Hui, et al.
Publicado: (2020)

EETs alleviate alveolar epithelial cell senescence by inhibiting endoplasmic reticulum stress through the Trim25/Keap1/Nrf2 axis
por: Zhang, Chen-Yu, et al.
Publicado: (2023)

Fn14 exacerbates acute lung injury by activating the NLRP3 inflammasome in mice
por: Guan, Xin-Xin, et al.
Publicado: (2022)

Transcriptome Analysis of Selenium-Treated Porcine Alveolar Macrophages Against Lipopolysaccharide Infection
por: Liu, Jia-Xuan, et al.
Publicado: (2021)

Maresin Conjugates in Tissue Regeneration 1 improves alveolar fluid clearance by up‐regulating alveolar ENaC, Na, K‐ATPase in lipopolysaccharide‐induced acute lung injury
por: Han, Jun, et al.
Publicado: (2020)

TREM-1 governs NLRP3 inflammasome activation of macrophages by firing up glycolysis in acute lung injury
por: Zhong, Wen-Jing, et al.
Publicado: (2023)

Activation of NLRP3 inflammasome up-regulates TREM-1 expression in murine macrophages via HMGB1 and IL-18
por: Zhong, Wen-Jing, et al.
Publicado: (2020)

Blocking triggering receptor expressed on myeloid cells-1 attenuates lipopolysaccharide-induced acute lung injury via inhibiting NLRP3 inflammasome activation
por: Liu, Tian, et al.
Publicado: (2016)

Continuous purification and culture of rat type 1 and type 2 alveolar epithelial cells by magnetic cell sorting
por: Liu, Di, et al.
Publicado: (2022)

A Novel Model Based on Necroptosis-Related Genes for Predicting Prognosis of Patients With Prostate Adenocarcinoma
por: Li, Xin-yu, et al.
Publicado: (2022)

Identification and Quantification of Necroptosis Landscape on Therapy and Prognosis in Kidney Renal Clear Cell Carcinoma
por: Xin, Sheng, et al.
Publicado: (2022)

Diethyl citrate and sodium citrate reduce the cytotoxic effects of nanosized hydroxyapatite crystals on mouse vascular smooth muscle cells
por: Zhang, Chong-Yu, et al.
Publicado: (2017)

Clinical Implications of Necroptosis Genes Expression for Cancer Immunity and Prognosis: A Pan-Cancer Analysis
por: Li, Xin-yu, et al.
Publicado: (2022)

Electrotaxis of alveolar epithelial cells in direct-current electric fields
por: Yang, Chao-Yue, et al.
Publicado: (2023)

The role of necroptosis in disease and treatment
por: Liu, Xiaoxiao, et al.
Publicado: (2021)

Epoxyeicosatrienoic Acids Inhibit the Activation of Murine Fibroblasts by Blocking the TGF-β1-Smad2/3 Signaling in a PPARγ-Dependent Manner
por: Tao, Jia-Hao, et al.
Publicado: (2022)

Necroptosis Underlies Hepatic Damage in a Piglet Model of Lipopolysaccharide-Induced Sepsis
por: Xu, Qiao, et al.
Publicado: (2021)

Protective Effects of Hydrogen-Rich Saline Against Lipopolysaccharide-Induced Alveolar Epithelial-to-Mesenchymal Transition and Pulmonary Fibrosis
por: Dong, Wen-Wen, et al.
Publicado: (2017)

Loss of MLKL ameliorates liver fibrosis by inhibiting hepatocyte necroptosis and hepatic stellate cell activation
por: Guo, Ren, et al.
Publicado: (2022)

TNF-mediated alveolar macrophage necroptosis drives disease pathogenesis during respiratory syncytial virus infection
por: Santos, Leonardo Duarte, et al.
Publicado: (2021)

IL-33/ST2 axis promotes glioblastoma cell invasion by accumulating tenascin-C
por: Zhang, Jian-fei, et al.
Publicado: (2019)

RIP1 Perturbation Induces Chondrocyte Necroptosis and Promotes Osteoarthritis Pathogenesis via Targeting BMP7
por: Cheng, Jin, et al.
Publicado: (2021)

Necroptosis is active and contributes to intestinal injury in a piglet model with lipopolysaccharide challenge
por: Liu, Yulan, et al.
Publicado: (2021)

LECT2 drives haematopoietic stem cell expansion and mobilization via regulating the macrophages and osteolineage cells
por: Lu, Xin-Jiang, et al.
Publicado: (2016)

Exosomal STIMATE derived from type II alveolar epithelial cells controls metabolic reprogramming of tissue-resident alveolar macrophages
por: Feng, Zunyong, et al.
Publicado: (2023)

Augmenter of liver regeneration protects the kidney against ischemia-reperfusion injury by inhibiting necroptosis
por: Liao, Yue-Juan, et al.
Publicado: (2022)

Identification of a novel necroptosis-associated miRNA signature for predicting the prognosis in head and neck squamous cell carcinoma
por: Guan, Jiezhong, et al.
Publicado: (2022)

Syndecan-1 Shedding by Matrix Metalloproteinase-9 Signaling Regulates Alveolar Epithelial Tight Junction in Lipopolysaccharide-Induced Early Acute Lung Injury
por: Zhang, Dong, et al.
Publicado: (2021)

Nephropathy Is Aggravated by Fatty Acids in Diabetic Kidney Disease through Tubular Epithelial Cell Necroptosis and Is Alleviated by an RIPK-1 Inhibitor
por: Yu, Qi, et al.
Publicado: (2023)

A bibliometric analysis of ferroptosis, necroptosis, pyroptosis, and cuproptosis in cancer from 2012 to 2022
por: Miao, Yan-Dong, et al.
Publicado: (2023)

Autophagy-Related LC3 Accumulation Interacted Directly With LIR Containing RIPK1 and RIPK3, Stimulating Necroptosis in Hypoxic Cardiomyocytes
por: Huang, Yao, et al.
Publicado: (2021)

The Immune System Drives Synapse Loss During Lipopolysaccharide-Induced Learning and Memory Impairment in Mice
por: Xin, Yi-Rong, et al.
Publicado: (2019)

Upregulation of FOXO1 contributes to lipopolysaccharide-induced pulmonary endothelial injury by induction of autophagy
por: Zhao, Ying, et al.
Publicado: (2022)

Bibliometric analysis of publications on necroptosis from 2001 to 2021
por: Liu, Yang, et al.
Publicado: (2022)

Identification of Piperlongumine as Potent Inhibitor of Necroptosis
por: He, Xiaoyan, et al.
Publicado: (2023)

Hypoxia-reoxygenation induced necroptosis in cultured rat renal tubular epithelial cell line
por: Zhu, Changlai, et al.
Publicado: (2018)

Rapid detection of pneumothorax by ultrasonography in patients with multiple trauma
por: Zhang, Mao, et al.
Publicado: (2006)

Cannot write session to /tmp/vufind_sessions/sess_54p2v93r73ce5snrak1svksshr