Targeting endogenous kidney regeneration using anti-IL11 therapy in acute and chronic models of kidney disease

The kidney has large regenerative capacity, but this is compromised when kidney damage is excessive and renal tubular epithelial cells (TECs) undergo SNAI1-driven growth arrest. Here we investigate the role of IL11 in TECs, kidney injury and renal repair. IL11 stimulation of TECs induces ERK- and p9...

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Detalles Bibliográficos
Autores principales: Widjaja, Anissa A., Viswanathan, Sivakumar, Shekeran, Shamini G., Adami, Eleonora, Lim, Wei-Wen, Chothani, Sonia, Tan, Jessie, Goh, Joyce Wei Ting, Chen, Hui Mei, Lim, Sze Yun, Boustany-Kari, Carine M., Hawkins, Julie, Petretto, Enrico, Hübner, Norbert, Schafer, Sebastian, Coffman, Thomas M., Cook, Stuart A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9723120/
https://www.ncbi.nlm.nih.gov/pubmed/36470928
http://dx.doi.org/10.1038/s41467-022-35306-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9723120/
https://www.ncbi.nlm.nih.gov/pubmed/36470928
http://dx.doi.org/10.1038/s41467-022-35306-1

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