Disruption of hippocampal neuronal circuit function depends upon behavioral state in the APP/PS1 mouse model of Alzheimer’s disease

The Alzheimer’s disease-associated peptide amyloid-beta (Aβ) has been associated with neuronal hyperactivity under anesthesia, but clinical trials of anticonvulsants or neural system suppressors have, so far, failed to improve symptoms in AD. Using simultaneous hippocampal calcium imaging and electr...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhou, Heng, Li, Hanyan, Gowravaram, Niket, Quan, Moqin, Kausar, Naila, Gomperts, Stephen N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9723144/
https://www.ncbi.nlm.nih.gov/pubmed/36471155
http://dx.doi.org/10.1038/s41598-022-25364-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9723144/
https://www.ncbi.nlm.nih.gov/pubmed/36471155
http://dx.doi.org/10.1038/s41598-022-25364-2

Ejemplares similares