The equilibrium of tumor suppression: DUBs as active regulators of PTEN

PTEN is among the most commonly lost or mutated tumor suppressor genes in human cancer. PTEN, a bona fide lipid phosphatase that antagonizes the highly oncogenic PI3K-AKT-mTOR pathway, is considered a major dose-dependent tumor suppressor. Although PTEN function can be compromised by genetic mutatio...

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Detalles Bibliográficos
Autores principales: Christine, Audrey, Park, Mi Kyung, Song, Su Jung, Song, Min Sup
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9723170/
https://www.ncbi.nlm.nih.gov/pubmed/36385557
http://dx.doi.org/10.1038/s12276-022-00887-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9723170/
https://www.ncbi.nlm.nih.gov/pubmed/36385557
http://dx.doi.org/10.1038/s12276-022-00887-w

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