A FFAR1 full agonist restores islet function in models of impaired glucose-stimulated insulin secretion and diabetic non-human primates

The free fatty acid receptor 1 (FFAR1/GPR40) mediates fatty acid-induced insulin secretion from pancreatic β-cells. At least 3 distinct binding sites exist on the FFAR1 receptor and numerous synthetic ligands have been investigated for their anti-diabetic actions. Fasiglifam, binds to site-1 and sti...

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Detalles Bibliográficos
Autores principales: Rady, Brian, Liu, Jianying, Huang, Hui, Bakaj, Ivona, Qi, Jenson, Lee, S. P., Martin, Tonya, Norquay, Lisa, Player, Mark, Pocai, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9723222/
https://www.ncbi.nlm.nih.gov/pubmed/36482991
http://dx.doi.org/10.3389/fendo.2022.1061688

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9723222/
https://www.ncbi.nlm.nih.gov/pubmed/36482991
http://dx.doi.org/10.3389/fendo.2022.1061688

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