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Locus coeruleus integrity correlates with inhibitory functions of the fronto-subthalamic ‘hyperdirect’ pathway in Parkinson’s disease

A long-running debate concerns whether dopamine or noradrenaline deficiency drives response disinhibition in Parkinson’s disease (PD). This study aimed to investigate whether damage to the locus coeruleus (LC) or substantia nigra (SN) might impact inhibitory functions of the fronto-subthalamic hyper...

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Detalles Bibliográficos
Autores principales: Xu, Biman, He, Tingting, Lu, Yuan, Jia, Jia, Sahakian, Barbara J., Robbins, Trevor W., Jin, Lirong, Ye, Zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9723406/
https://www.ncbi.nlm.nih.gov/pubmed/36510410
http://dx.doi.org/10.1016/j.nicl.2022.103276