Enteroviral 2C protein is an RNA-stimulated ATPase and uses a two-step mechanism for binding to RNA and ATP

The enteroviral 2C protein is a therapeutic target, but the absence of a mechanistic framework for this enzyme limits our understanding of inhibitor mechanisms. Here, we use poliovirus 2C and a derivative thereof to elucidate the first biochemical mechanism for this enzyme and confirm the applicabil...

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Detalles Bibliográficos
Autores principales: Yeager, Calvin, Carter, Griffin, Gohara, David W, Yennawar, Neela H, Enemark, Eric J, Arnold, Jamie J, Cameron, Craig E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9723501/
https://www.ncbi.nlm.nih.gov/pubmed/36399514
http://dx.doi.org/10.1093/nar/gkac1054

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9723501/
https://www.ncbi.nlm.nih.gov/pubmed/36399514
http://dx.doi.org/10.1093/nar/gkac1054

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