PARP1 proximity proteomics reveals interaction partners at stressed replication forks

PARP1 mediates poly-ADP-ribosylation of proteins on chromatin in response to different types of DNA lesions. PARP inhibitors are used for the treatment of BRCA1/2-deficient breast, ovarian, and prostate cancer. Loss of DNA replication fork protection is proposed as one mechanism that contributes to...

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Detalles Bibliográficos
Autores principales: Mosler, Thorsten, Baymaz, H Irem, Gräf, Justus F, Mikicic, Ivan, Blattner, Georges, Bartlett, Edward, Ostermaier, Matthias, Piccinno, Rossana, Yang, Jiwen, Voigt, Andrea, Gatti, Marco, Pellegrino, Stefania, Altmeyer, Matthias, Luck, Katja, Ahel, Ivan, Roukos, Vassilis, Beli, Petra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9723622/
https://www.ncbi.nlm.nih.gov/pubmed/36350633
http://dx.doi.org/10.1093/nar/gkac948

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9723622/
https://www.ncbi.nlm.nih.gov/pubmed/36350633
http://dx.doi.org/10.1093/nar/gkac948

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