Synthesis of point-modified mRNA

Synthetic mRNA has recently moved into the focus of therapeutic and vaccination efforts. Incorporation of modified nucleotides during in vitro transcription can improve translation and attenuate immunogenicity, but is limited to triphosphate nucleotides which are accepted by RNA polymerases, and the...

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Detalles Bibliográficos
Autores principales: Hertler, Jasmin, Slama, Kaouthar, Schober, Benedikt, Özrendeci, Zeynep, Marchand, Virginie, Motorin, Yuri, Helm, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9723659/
https://www.ncbi.nlm.nih.gov/pubmed/36062567
http://dx.doi.org/10.1093/nar/gkac719

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9723659/
https://www.ncbi.nlm.nih.gov/pubmed/36062567
http://dx.doi.org/10.1093/nar/gkac719

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