Structural and dynamic basis of DNA capture and translocation by mitochondrial Twinkle helicase

Twinkle is a mitochondrial replicative helicase which can self-load onto and unwind mitochondrial DNA. Nearly 60 mutations on Twinkle have been linked to human mitochondrial diseases. Using cryo-electron microscopy (cryo-EM) and high-speed atomic force microscopy (HS-AFM), we obtained the atomic-res...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Zhuo, Kaur, Parminder, Lo, Chen-Yu, Chopra, Neil, Smith, Jamie, Wang, Hong, Gao, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9723800/
https://www.ncbi.nlm.nih.gov/pubmed/36400570
http://dx.doi.org/10.1093/nar/gkac1089

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9723800/
https://www.ncbi.nlm.nih.gov/pubmed/36400570
http://dx.doi.org/10.1093/nar/gkac1089

Ejemplares similares