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Structural and dynamic basis of DNA capture and translocation by mitochondrial Twinkle helicase

Twinkle is a mitochondrial replicative helicase which can self-load onto and unwind mitochondrial DNA. Nearly 60 mutations on Twinkle have been linked to human mitochondrial diseases. Using cryo-electron microscopy (cryo-EM) and high-speed atomic force microscopy (HS-AFM), we obtained the atomic-res...

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Detalles Bibliográficos
Autores principales:	Li, Zhuo, Kaur, Parminder, Lo, Chen-Yu, Chopra, Neil, Smith, Jamie, Wang, Hong, Gao, Yang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9723800/ https://www.ncbi.nlm.nih.gov/pubmed/36400570 http://dx.doi.org/10.1093/nar/gkac1089

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