α-Tubulin detyrosination links the suppression of MCAK activity with taxol cytotoxicity

α/β-Tubulin posttranslational modifications (PTMs) generate microtubule diversity, but whether they account for cancer cell resistance to microtubule-targeting drugs remains unknown. Here, we performed a pilot dissection of the “cancer tubulin code” using the NCI-60 cancer cell panel. We found that...

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Detalles Bibliográficos
Autores principales: Lopes, Danilo, Seabra, Alexandre L., Orr, Bernardo, Maiato, Helder
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9723805/
https://www.ncbi.nlm.nih.gov/pubmed/36459065
http://dx.doi.org/10.1083/jcb.202205092

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9723805/
https://www.ncbi.nlm.nih.gov/pubmed/36459065
http://dx.doi.org/10.1083/jcb.202205092

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