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Residues forming the gating regions of asymmetric multidrug transporter Pdr5 also play roles in conformational switching and protein folding
ATP-binding cassette (ABC) multidrug transporters are large, polytopic membrane proteins that exhibit astonishing promiscuity for their transport substrates. These transporters unidirectionally efflux thousands of structurally and functionally distinct compounds. To preclude the reentry of xenobioti...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9723933/ https://www.ncbi.nlm.nih.gov/pubmed/36370844 http://dx.doi.org/10.1016/j.jbc.2022.102689 |