Residues forming the gating regions of asymmetric multidrug transporter Pdr5 also play roles in conformational switching and protein folding

ATP-binding cassette (ABC) multidrug transporters are large, polytopic membrane proteins that exhibit astonishing promiscuity for their transport substrates. These transporters unidirectionally efflux thousands of structurally and functionally distinct compounds. To preclude the reentry of xenobioti...

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Detalles Bibliográficos
Autores principales: Alhumaidi, Maryam, Nentwig, Lea-Marie, Rahman, Hadiar, Schmitt, Lutz, Rudrow, Andrew, Harris, Andrzej, Dillon, Cierra, Restrepo, Lucas, Lamping, Erwin, Arya, Nidhi, Ambudkar, Suresh V., Choy, John S., Golin, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9723933/
https://www.ncbi.nlm.nih.gov/pubmed/36370844
http://dx.doi.org/10.1016/j.jbc.2022.102689

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