Design, Synthesis, and Evaluation of a Cross-Linked Oligonucleotide as the First Nanomolar Inhibitor of APOBEC3A

[Image: see text] Drug resistance is a major problem associated with anticancer chemo- and immunotherapies. Recent advances in the understanding of resistance mechanisms have revealed that enzymes of the APOBEC3 (A3) family contribute to the development of drug resistance in multiple cancers. A3 enz...

Descripción completa

Detalles Bibliográficos
Autores principales: Kurup, Harikrishnan M., Kvach, Maksim V., Harjes, Stefan, Barzak, Fareeda M., Jameson, Geoffrey B., Harjes, Elena, Filichev, Vyacheslav V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9724085/
https://www.ncbi.nlm.nih.gov/pubmed/36302365
http://dx.doi.org/10.1021/acs.biochem.2c00449

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9724085/
https://www.ncbi.nlm.nih.gov/pubmed/36302365
http://dx.doi.org/10.1021/acs.biochem.2c00449

Ejemplares similares