One-Pot Synthesis of Styrene Derivatives from Allyl Silanes via B(C(6)F(5))(3)-Catalyzed Isomerization–Hiyama Coupling

[Image: see text] Herein, we report a one-pot synthesis of styrene derivatives via a novel B(C(6)F(5))(3)-catalyzed E-selective isomerization of readily accessible allyl silanes and subsequent Hiyama coupling of the versatile alkenyl silane intermediates. This one-pot, two-step approach enables acce...

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Autores principales: Kustiana, Betty A., Melen, Rebecca L., Morrill, Louis C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9724089/
https://www.ncbi.nlm.nih.gov/pubmed/36394303
http://dx.doi.org/10.1021/acs.orglett.2c03584
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author Kustiana, Betty A.
Melen, Rebecca L.
Morrill, Louis C.
author_facet Kustiana, Betty A.
Melen, Rebecca L.
Morrill, Louis C.
author_sort Kustiana, Betty A.
collection PubMed
description [Image: see text] Herein, we report a one-pot synthesis of styrene derivatives via a novel B(C(6)F(5))(3)-catalyzed E-selective isomerization of readily accessible allyl silanes and subsequent Hiyama coupling of the versatile alkenyl silane intermediates. This one-pot, two-step approach enables access to a broad range of styrene derivatives, including those containing Lewis basic functional groups, that cannot be accessed via the previously developed B(C(6)F(5))(3)-catalyzed isomerization of allyl benzenes.
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spelling pubmed-97240892022-12-07 One-Pot Synthesis of Styrene Derivatives from Allyl Silanes via B(C(6)F(5))(3)-Catalyzed Isomerization–Hiyama Coupling Kustiana, Betty A. Melen, Rebecca L. Morrill, Louis C. Org Lett [Image: see text] Herein, we report a one-pot synthesis of styrene derivatives via a novel B(C(6)F(5))(3)-catalyzed E-selective isomerization of readily accessible allyl silanes and subsequent Hiyama coupling of the versatile alkenyl silane intermediates. This one-pot, two-step approach enables access to a broad range of styrene derivatives, including those containing Lewis basic functional groups, that cannot be accessed via the previously developed B(C(6)F(5))(3)-catalyzed isomerization of allyl benzenes. American Chemical Society 2022-11-17 2022-12-02 /pmc/articles/PMC9724089/ /pubmed/36394303 http://dx.doi.org/10.1021/acs.orglett.2c03584 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Kustiana, Betty A.
Melen, Rebecca L.
Morrill, Louis C.
One-Pot Synthesis of Styrene Derivatives from Allyl Silanes via B(C(6)F(5))(3)-Catalyzed Isomerization–Hiyama Coupling
title One-Pot Synthesis of Styrene Derivatives from Allyl Silanes via B(C(6)F(5))(3)-Catalyzed Isomerization–Hiyama Coupling
title_full One-Pot Synthesis of Styrene Derivatives from Allyl Silanes via B(C(6)F(5))(3)-Catalyzed Isomerization–Hiyama Coupling
title_fullStr One-Pot Synthesis of Styrene Derivatives from Allyl Silanes via B(C(6)F(5))(3)-Catalyzed Isomerization–Hiyama Coupling
title_full_unstemmed One-Pot Synthesis of Styrene Derivatives from Allyl Silanes via B(C(6)F(5))(3)-Catalyzed Isomerization–Hiyama Coupling
title_short One-Pot Synthesis of Styrene Derivatives from Allyl Silanes via B(C(6)F(5))(3)-Catalyzed Isomerization–Hiyama Coupling
title_sort one-pot synthesis of styrene derivatives from allyl silanes via b(c(6)f(5))(3)-catalyzed isomerization–hiyama coupling
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9724089/
https://www.ncbi.nlm.nih.gov/pubmed/36394303
http://dx.doi.org/10.1021/acs.orglett.2c03584
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