Inhaled seralutinib exhibits potent efficacy in models of pulmonary arterial hypertension

BACKGROUND: Signalling through platelet-derived growth factor receptor (PDGFR), colony-stimulating factor 1 receptor (CSF1R) and mast/stem cell growth factor receptor kit (c-KIT) plays a critical role in pulmonary arterial hypertension (PAH). We examined the preclinical efficacy of inhaled seralutin...

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Detalles Bibliográficos
Autores principales: Galkin, Anna, Sitapara, Ravikumar, Clemons, Bryan, Garcia, Eduardo, Kennedy, Michael, Guimond, David, Carter, Laura L., Douthitt, Ashley, Osterhout, Robin, Gandjeva, Aneta, Slee, Deborah, Salter-Cid, Luisa, Tuder, Rubin M., Zisman, Lawrence S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2022
Materias:
Original Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9724289/
https://www.ncbi.nlm.nih.gov/pubmed/35680144
http://dx.doi.org/10.1183/13993003.02356-2021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9724289/
https://www.ncbi.nlm.nih.gov/pubmed/35680144
http://dx.doi.org/10.1183/13993003.02356-2021

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