Discovery of a pyrano[2,3-b]pyridine derivative YX-2102 as a cannabinoid receptor 2 agonist for alleviating lung fibrosis

BACKGROUND: Pharmacological modulation of cannabinoid 2 receptor (CB2R) is a promising therapeutic strategy for pulmonary fibrosis (PF). Thus, to develop CB2R selective ligands with new chemical space has attracted much research interests. This work aims to discover a novel CB2R agonist from an in-h...

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Detalles Bibliográficos
Autores principales: Liu, Tao, Gu, Jing, Yuan, Yi, Yang, Qunfang, Zheng, Peng-Fei, Shan, Changyu, Wang, Fangqin, Li, Hongwei, Xie, Xiang-Qun, Chen, Xiao-Hong, Ouyang, Qin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9724349/
https://www.ncbi.nlm.nih.gov/pubmed/36474298
http://dx.doi.org/10.1186/s12967-022-03773-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9724349/
https://www.ncbi.nlm.nih.gov/pubmed/36474298
http://dx.doi.org/10.1186/s12967-022-03773-1

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