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GCN5L1-mediated TFAM acetylation at K76 participates in mitochondrial biogenesis in acute kidney injury
BACKGROUND: Mitochondrial dysfunction is an important pathogenic event in acute kidney injury (AKI). GCN5L1 is a specific acetyltransferase in mitochondria, which regulates glucose and fatty acid metabolism. However, the role of GCN5L1 in mitochondrial dysfunction and the pathogenesis of ischemic AK...
Autores principales: | Lv, Tingting, Zhang, Yu, Ji, XingZhao, Sun, Shengnan, Xu, Li, Ma, Weixia, Liu, Yi, Wan, Qiang |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9724393/ https://www.ncbi.nlm.nih.gov/pubmed/36474281 http://dx.doi.org/10.1186/s12967-022-03782-0 |
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