Nsp16 shields SARS–CoV‐2 from efficient MDA5 sensing and IFIT1‐mediated restriction

Methylation of the mRNA 5′ cap by cellular methyltransferases enables efficient translation and avoids recognition by innate immune factors. Coronaviruses encode viral 2′‐O‐methyltransferases to shield their RNA from host factors. Here, we generate recombinant SARS–CoV‐2 harboring a catalytically in...

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Detalles Bibliográficos
Autores principales: Russ, Alina, Wittmann, Sabine, Tsukamoto, Yuta, Herrmann, Alexandra, Deutschmann, Janina, Lagisquet, Justine, Ensser, Armin, Kato, Hiroki, Gramberg, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9724656/
https://www.ncbi.nlm.nih.gov/pubmed/36285486
http://dx.doi.org/10.15252/embr.202255648

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9724656/
https://www.ncbi.nlm.nih.gov/pubmed/36285486
http://dx.doi.org/10.15252/embr.202255648

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