Stimulation of interferon-β responses by aberrant SARS-CoV-2 small viral RNAs acting as retinoic acid-inducible gene-I agonists

Patients with severe COVID-19 exhibit a cytokine storm characterized by greatly elevated levels of cytokines. Despite this, the interferon (IFN) response is delayed, contributing to disease progression. Here, we report that SARS-CoV-2 excessively generates small viral RNAs (svRNAs) encoding exact 5′...

Descripción completa

Detalles Bibliográficos
Autores principales: Arai, Yasuha, Yamanaka, Itaru, Okamoto, Toru, Isobe, Ayana, Nakai, Naomi, Kamimura, Naoko, Suzuki, Tatsuya, Daidoji, Tomo, Ono, Takao, Nakaya, Takaaki, Matsumoto, Kazuhiko, Okuzaki, Daisuke, Watanabe, Yohei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9726650/
https://www.ncbi.nlm.nih.gov/pubmed/36507221
http://dx.doi.org/10.1016/j.isci.2022.105742

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9726650/
https://www.ncbi.nlm.nih.gov/pubmed/36507221
http://dx.doi.org/10.1016/j.isci.2022.105742

Ejemplares similares