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Stimulation of interferon-β responses by aberrant SARS-CoV-2 small viral RNAs acting as retinoic acid-inducible gene-I agonists

Patients with severe COVID-19 exhibit a cytokine storm characterized by greatly elevated levels of cytokines. Despite this, the interferon (IFN) response is delayed, contributing to disease progression. Here, we report that SARS-CoV-2 excessively generates small viral RNAs (svRNAs) encoding exact 5′...

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Detalles Bibliográficos
Autores principales:	Arai, Yasuha, Yamanaka, Itaru, Okamoto, Toru, Isobe, Ayana, Nakai, Naomi, Kamimura, Naoko, Suzuki, Tatsuya, Daidoji, Tomo, Ono, Takao, Nakaya, Takaaki, Matsumoto, Kazuhiko, Okuzaki, Daisuke, Watanabe, Yohei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9726650/ https://www.ncbi.nlm.nih.gov/pubmed/36507221 http://dx.doi.org/10.1016/j.isci.2022.105742

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