Self-nanoemulsifying drug delivery system (SNEDDS) mediated improved oral bioavailability of thymoquinone: optimization, characterization, pharmacokinetic, and hepatotoxicity studies

Thymoquinone (TQ) is an antioxidant, anti-inflammatory, and hepatoprotective compound obtained from the black seed oil of Nigella sativa. However, high hydrophobicity, instability at higher pH levels, photosensitivity, and low oral bioavailability hinder its delivery to the target tissues. A self-na...

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Detalles Bibliográficos
Autores principales: Rathore, Charul, Hemrajani, Chetna, Sharma, Abhishek Kumar, Gupta, Piyush Kumar, Jha, Niraj Kumar, Aljabali, Alaa A. A., Gupta, Gaurav, Singh, Sachin Kumar, Yang, Jen-Chang, Dwivedi, Ram Prakash, Dua, Kamal, Chellappan, Dinesh Kumar, Negi, Poonam, Tambuwala, Murtaza M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9726673/
https://www.ncbi.nlm.nih.gov/pubmed/35831776
http://dx.doi.org/10.1007/s13346-022-01193-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9726673/
https://www.ncbi.nlm.nih.gov/pubmed/35831776
http://dx.doi.org/10.1007/s13346-022-01193-8

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