The role of auxiliary domains in modulating CHD4 activity suggests mechanistic commonality between enzyme families

CHD4 is an essential, widely conserved ATP-dependent translocase that is also a broad tumour dependency. In common with other SF2-family chromatin remodelling enzymes, it alters chromatin accessibility by repositioning histone octamers. Besides the helicase and adjacent tandem chromodomains and PHD...

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Detalles Bibliográficos
Autores principales: Zhong, Yichen, Moghaddas Sani, Hakimeh, Paudel, Bishnu P., Low, Jason K. K., Silva, Ana P. G., Mueller, Stefan, Deshpande, Chandrika, Panjikar, Santosh, Reid, Xavier J., Bedward, Max J., van Oijen, Antoine M., Mackay, Joel P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9726900/
https://www.ncbi.nlm.nih.gov/pubmed/36473839
http://dx.doi.org/10.1038/s41467-022-35002-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9726900/
https://www.ncbi.nlm.nih.gov/pubmed/36473839
http://dx.doi.org/10.1038/s41467-022-35002-0

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