Natural product preferentially targets redox and metabolic adaptations and aberrantly active STAT3 to inhibit breast tumor growth in vivo

Dysregulated gene expression programs and redox and metabolic adaptations allow cancer cells to survive under high oxidative burden. These mechanisms also represent therapeutic vulnerabilities. Using triple-negative breast cancer (TNBC) as a model, we show that compared to normal human breast epithe...

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Detalles Bibliográficos
Autores principales: Zhu, Yinsong, Yue, Peibin, Dickinson, Cody F., Yang, Justin K., Datanagan, Kyrstin, Zhai, Ning, Zhang, Yi, Miklossy, Gabriella, Lopez-Tapia, Francisco, Tius, Marcus A., Turkson, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9726930/
https://www.ncbi.nlm.nih.gov/pubmed/36473850
http://dx.doi.org/10.1038/s41419-022-05477-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9726930/
https://www.ncbi.nlm.nih.gov/pubmed/36473850
http://dx.doi.org/10.1038/s41419-022-05477-2

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