Backbone amides are determinants of Cl(−) selectivity in CLC ion channels

Chloride homeostasis is regulated in all cellular compartments. CLC-type channels selectively transport Cl(−) across biological membranes. It is proposed that side-chains of pore-lining residues determine Cl(−) selectivity in CLC-type channels, but their spatial orientation and contributions to sele...

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Detalles Bibliográficos
Autores principales: Leisle, Lilia, Lam, Kin, Dehghani-Ghahnaviyeh, Sepehr, Fortea, Eva, Galpin, Jason D., Ahern, Christopher A., Tajkhorshid, Emad, Accardi, Alessio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9726985/
https://www.ncbi.nlm.nih.gov/pubmed/36473856
http://dx.doi.org/10.1038/s41467-022-35279-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9726985/
https://www.ncbi.nlm.nih.gov/pubmed/36473856
http://dx.doi.org/10.1038/s41467-022-35279-1

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