Cargando…

Metals-triggered compound CDPDP exhibits anti-arthritic behavior by downregulating the inflammatory cytokines, and modulating the oxidative storm in mice models with extensive ADMET, docking and simulation studies

Triggering through abiotic stress, including chemical triggers like heavy metals, is a new technique for drug discovery. In this research, the effect of heavy metal Nickel on actinobacteria Streptomyces sp. SH-1327 to obtain a stress-derived compound was firstly investigated. A new compound cyclo-(D...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hassan, Syed Shams ul, Abbas, Syed Qamar, Muhammad, Ishaq, Wu, Jia-Jia, Yan, Shi-Kai, Ali, Fawad, Majid, Muhammad, Jin, Hui-Zi, Bungau, Simona
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9727203/ https://www.ncbi.nlm.nih.gov/pubmed/36506587 http://dx.doi.org/10.3389/fphar.2022.1053744

Ejemplares similares

Stress Driven Discovery of Natural Products From Actinobacteria with Anti-Oxidant and Cytotoxic Activities Including Docking and ADMET Properties
por: Hassan, Syed Shams ul, et al.
Publicado: (2021)

A Comprehensive In Silico Exploration of Pharmacological Properties, Bioactivities, Molecular Docking, and Anticancer Potential of Vieloplain F from Xylopia vielana Targeting B-Raf Kinase
por: Hassan, Syed Shams ul, et al.
Publicado: (2022)

Isoprenaline and salbutamol inhibit pyroptosis and promote mitochondrial biogenesis in arthritic chondrocytes by downregulating β-arrestin and GRK2
por: Ajmal, Iqra, et al.
Publicado: (2022)

Genome-wide Meta-analysis Reveals New Gene Signatures and Potential Drug Targets of Hypertension
por: Ali, Fawad, et al.
Publicado: (2022)

Ferroptosis: A New Road towards Cancer Management
por: Bano, Iqra, et al.
Publicado: (2022)

In-Silico Lead Druggable Compounds Identification against SARS COVID-19 Main Protease Target from In-House, Chembridge and Zinc Databases by Structure-Based Virtual Screening, Molecular Docking and Molecular Dynamics Simulations
por: Ghufran, Mehreen, et al.
Publicado: (2023)

In-Vitro, In-Vivo, Molecular Docking and ADMET Studies of 2-Substituted 3,7-Dihydroxy-4H-chromen-4-one for Oxidative Stress, Inflammation and Alzheimer’s Disease
por: Mahnashi, Mater H., et al.
Publicado: (2022)

Cytotoxic effects of extracts and isolated compounds from Ifloga spicata (forssk.) sch. bip against HepG-2 cancer cell line: Supported by ADMET analysis and molecular docking
por: Hussain, Sajid, et al.
Publicado: (2022)

Toxicity evaluation induced by single and 28-days repeated exposure of withametelin and daturaolone in Sprague Dawley rats
por: Baig, Muhammad Waleed, et al.
Publicado: (2022)

An Extensive Pharmacological Evaluation of New Anti-Cancer Triterpenoid (Nummularic Acid) from Ipomoea batatas through In Vitro, In Silico, and In Vivo Studies
por: Majid, Muhammad, et al.
Publicado: (2022)

Novel adamantyl clubbed iminothiazolidinones as promising elastase inhibitors: design, synthesis, molecular docking, ADMET and DFT studies
por: Ahmed, Atteeque, et al.
Publicado: (2022)

Quantitative Real-Time Analysis of Differentially Expressed Genes in Peripheral Blood Samples of Hypertension Patients
por: Ali, Fawad, et al.
Publicado: (2022)

Ameliorative Effect of Structurally Divergent Oleanane Triterpenoid, 3-Epifriedelinol from Ipomoea batatas against BPA-Induced Gonadotoxicity by Targeting PARP and NF-κB Signaling in Rats
por: Majid, Muhammad, et al.
Publicado: (2022)

Anti-Inflammatory, Analgesic and Antioxidant Potential of New (2S,3S)-2-(4-isopropylbenzyl)-2-methyl-4-nitro-3-phenylbutanals and Their Corresponding Carboxylic Acids through In Vitro, In Silico and In Vivo Studies
por: Mahmood, Fawad, et al.
Publicado: (2022)

Dihydropyrazole Derivatives Act as Potent α-Amylase Inhibitors and Free Radical Scavengers: Synthesis, Bioactivity Evaluation, Structure–Activity Relationship, ADMET, and Molecular Docking Studies
por: Ali, Arif, et al.
Publicado: (2023)

Pharmacological basis of bergapten in gastrointestinal diseases focusing on H(+)/K(+) ATPase and voltage-gated calcium channel inhibition: A toxicological evaluation on vital organs
por: Aslam, Huma, et al.
Publicado: (2022)

Separation of Mandelic Acid by a Reactive Extraction Method Using Tertiary Amine in Different Organic Diluents
por: Kiriş, Barış, et al.
Publicado: (2022)

Molecular docking and ADMET analysis of hydroxamic acids as HDAC2 inhibitors
por: Alsawalha, Murad, et al.
Publicado: (2019)

Anti-diabetic Activity of Brucine in Streptozotocin-Induced Rats: In Silico, In Vitro, and In Vivo Studies
por: Khan, Naimat Ullah, et al.
Publicado: (2022)

A Comprehensive Review of Biological Roles and Interactions of Cullin-5 Protein
por: Bano, Iqra, et al.
Publicado: (2022)

Emodin alleviates chronic constriction injury-induced neuropathic pain and inflammation via modulating PPAR-gamma pathway
por: Badshah, Ismail, et al.
Publicado: (2023)

Pharmacological Basis of Rumex hastatus D. Don in Gastrointestinal Diseases with Focusing Effects on H(+)/K(+)-ATPase, Calcium Channels Inhibition and PDE Mediated Signaling: Toxicological Evaluation on Vital Organs
por: Qazi, Neelum Gul, et al.
Publicado: (2022)

Molecular docking, QSAR and ADMET studies of withanolide analogs against breast cancer
por: Yadav, Dharmendra K, et al.
Publicado: (2017)

3D-QSAR, docking and ADMET properties of aurone analogues as antimalarial agents
por: Hadni, Hanine, et al.
Publicado: (2020)

Integrated Bioinformatics-Based Subtractive Genomics Approach to Decipher the Therapeutic Drug Target and Its Possible Intervention against Brucellosis
por: Khan, Kanwal, et al.
Publicado: (2022)

Applications of Extracellular Vesicles in Nervous System Disorders: An Overview of Recent Advances
por: Khan, Safir Ullah, et al.
Publicado: (2022)

Ultrasonic-Assisted Synthesis of Benzofuran Appended Oxadiazole Molecules as Tyrosinase Inhibitors: Mechanistic Approach through Enzyme Inhibition, Molecular Docking, Chemoinformatics, ADMET and Drug-Likeness Studies
por: Irfan, Ali, et al.
Publicado: (2022)

Antibacterial, Anticandidal, and Antibiofilm Potential of Fenchone: In Vitro, Molecular Docking and In Silico/ADMET Study
por: Ahmad, Wasim, et al.
Publicado: (2022)

Homology modeling, docking, and ADMET studies of benzoheterocyclic 4-aminoquinolines analogs as inhibitors of Plasmodiumfalciparum
por: Ibrahim, Zakari Y., et al.
Publicado: (2023)

In Silico Strategies for Designing of Peptide Inhibitors of Oncogenic K-Ras G12V Mutant: Inhibiting Cancer Growth and Proliferation
por: Ghufran, Mehreen, et al.
Publicado: (2022)

Appraisal of selected ethnomedicinal plants as alternative therapies against onychomycosis: Evaluation of synergy and time-kill kinetics
por: Mohsin, Syeda Aroosa, et al.
Publicado: (2022)

Novel Isoxazole Derivative Attenuates Ethanol-Induced Gastric Mucosal Injury through Inhibition of H(+)/K(+)-ATPase Pump, Oxidative Stress and Inflammatory Pathways
por: Razzaq, Sidra, et al.
Publicado: (2022)

FP-ADMET: a compendium of fingerprint-based ADMET prediction models
por: Venkatraman, Vishwesh
Publicado: (2021)

Reprogramming tumor-associated macrophages as a unique approach to target tumor immunotherapy
por: Khan, Safir Ullah, et al.
Publicado: (2023)

Exfoliation of MoS(2) Quantum Dots: Recent Progress and Challenges
por: Ali, Luqman, et al.
Publicado: (2022)

Study of novel triazolo-benzodiazepine analogues as antidepressants targeting by molecular docking and ADMET properties prediction
por: Belhassan, Assia, et al.
Publicado: (2019)

Pyrazole, imidazole and triazole: In silico, docking and ADMET studies against SARS-CoV-2
por: Mohamed, Mounir, et al.
Publicado: (2023)

Emerging Biopharmaceuticals from Pimpinella Genus
por: Wu, Jiajia, et al.
Publicado: (2023)

Drug-1,3,4-Thiadiazole Conjugates as Novel Mixed-Type Inhibitors of Acetylcholinesterase: Synthesis, Molecular Docking, Pharmacokinetics, and ADMET Evaluation
por: Ujan, Rabail, et al.
Publicado: (2019)

Natural Products for Chronic Diseases: A Ray of Hope
por: Hassan, Syed Shams ul, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_scs4u29fa51q3hnuttoqfoe0mv