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Activation of metabotropic glutamate receptor 1 regulates hippocampal CA1 region excitability in rats with status epilepticus by suppressing the HCN1 channel

Dysregulation of hyperpolarization-activated cyclic nucleotide-gated cation (HCN) channels alters neuronal excitability. However, the role of HCN channels in status epilepticus is not fully understood. In this study, we established rat models of pentylenetetrazole-induced status epilepticus. We perf...

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Detalles Bibliográficos
Autores principales: Luo, Xiao-Dan, Xiang, Tao, Li, Si-Jun, Ma, Mei-Gang, Chen, Mei-Ling, Wu, Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9727425/
https://www.ncbi.nlm.nih.gov/pubmed/36018183
http://dx.doi.org/10.4103/1673-5374.350206