CRISPR/SaCas9 mutagenesis of stromal interaction molecule 1 in proopiomelanocortin neurons increases glutamatergic excitability and protects against diet-induced obesity

OBJECTIVE: Proopiomelanocortin (POMC) neurons are the key anorexigenic hypothalamic neuron for integrating metabolic cues to generate the appropriate output for maintaining energy homeostasis and express the requisite channels as a perfect synaptic integrator in this role. Similar to the metabolic h...

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Detalles Bibliográficos
Autores principales: Qiu, Jian, Bosch, Martha A., Stincic, Todd L., Hunker, Avery C., Zweifel, Larry S., Rønnekleiv, Oline K., Kelly, Martin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9727646/
https://www.ncbi.nlm.nih.gov/pubmed/36442744
http://dx.doi.org/10.1016/j.molmet.2022.101645

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9727646/
https://www.ncbi.nlm.nih.gov/pubmed/36442744
http://dx.doi.org/10.1016/j.molmet.2022.101645

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