SARS-CoV-2 down-regulates ACE2 through lysosomal degradation

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) utilizes its Spike (S) glycoprotein to bind to the angiotensin-converting enzyme 2 (ACE2) receptor for cellular entry. ACE2 is a critical negative regulator of the renin-angiotensin system and plays a protective role in preventing tissue i...

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Detalles Bibliográficos
Autores principales: Lu, Yi, Zhu, Qingwei, Fox, Douglas M., Gao, Carol, Stanley, Sarah A., Luo, Kunxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9727799/
https://www.ncbi.nlm.nih.gov/pubmed/36287912
http://dx.doi.org/10.1091/mbc.E22-02-0045

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9727799/
https://www.ncbi.nlm.nih.gov/pubmed/36287912
http://dx.doi.org/10.1091/mbc.E22-02-0045

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