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DNA damage-induced nuclear import of HSP90α is promoted by Aha1

The interplay between yHSP90α (Hsp82) and Rad51 has been implicated in the DNA double-strand break repair (DSB) pathway in yeast. Here we report that nuclear translocation of yHSP90α and its recruitment to the DSB end are essential for homologous recombination (HR)-mediated DNA repair in yeast. The...

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Detalles Bibliográficos
Autores principales: Fangaria, Nupur, Rani, Khushboo, Singh, Priyanka, Dey, Sandeep, Kumar, Kota Arun, Bhattacharyya, Sunanda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9727810/
https://www.ncbi.nlm.nih.gov/pubmed/36260391
http://dx.doi.org/10.1091/mbc.E21-11-0554