Tadalafil increases the antitumor activity of 5-FU through inhibiting PRMT5-mediated glycolysis and cell proliferation in colorectal cancer

BACKGROUND: Protein arginine methyltransferase 5 (PRMT5) is upregulated in multiple tumors and plays a pivotal role in cancer cell proliferation. However, the role of PRMT5 in colorectal cancer remains poorly understood. METHODS: We detected the expression level of PRMT5 and glycolytic enzymes using...

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Detalles Bibliográficos
Autores principales: Shen, Yao, Zhao, Pan, Dong, Kewei, Wang, Jiajia, Li, Huichen, Li, Mengyang, Li, Ruikai, Chen, Suning, Shen, Yuxia, Liu, Zhiyu, Xie, Mianjiao, Shen, Peng, Zhang, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9727889/
https://www.ncbi.nlm.nih.gov/pubmed/36474242
http://dx.doi.org/10.1186/s40170-022-00299-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9727889/
https://www.ncbi.nlm.nih.gov/pubmed/36474242
http://dx.doi.org/10.1186/s40170-022-00299-4

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