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Tadalafil increases the antitumor activity of 5-FU through inhibiting PRMT5-mediated glycolysis and cell proliferation in colorectal cancer

BACKGROUND: Protein arginine methyltransferase 5 (PRMT5) is upregulated in multiple tumors and plays a pivotal role in cancer cell proliferation. However, the role of PRMT5 in colorectal cancer remains poorly understood. METHODS: We detected the expression level of PRMT5 and glycolytic enzymes using...

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Detalles Bibliográficos
Autores principales:	Shen, Yao, Zhao, Pan, Dong, Kewei, Wang, Jiajia, Li, Huichen, Li, Mengyang, Li, Ruikai, Chen, Suning, Shen, Yuxia, Liu, Zhiyu, Xie, Mianjiao, Shen, Peng, Zhang, Jian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9727889/ https://www.ncbi.nlm.nih.gov/pubmed/36474242 http://dx.doi.org/10.1186/s40170-022-00299-4

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