Effective Blocking of Microbial Transcriptional Initiation by dCas9-NG-Mediated CRISPR Interference

CRISPR interference (CRISPRi) has been developed as a transcriptional control tool by inactivating the DNA cleavage ability of Cas9 nucleases to produce dCas9 (deactivated Cas9), and leaving dCas9 the ability to specifically bind to the target DNA sequence. CRISPR/Cas9 technology has limitations in...

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Detalles Bibliográficos
Autores principales: Kim, Bumjoon, Kim,, Hyun Ju, Lee, Sang Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Microbiology and Biotechnology 2020
Materias:
Research article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9728369/
https://www.ncbi.nlm.nih.gov/pubmed/32958732
http://dx.doi.org/10.4014/jmb.2008.08058

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9728369/
https://www.ncbi.nlm.nih.gov/pubmed/32958732
http://dx.doi.org/10.4014/jmb.2008.08058

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