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Direct formation and site-selective elaboration of methionine sulfoximine in polypeptides

Sulfoximines are emerging moieties for medicinal and biological chemistry, due in part to their efficacy in selective inhibition of amide-forming enzymes such as γ-glutamylcysteine synthetase. While small-molecule sulfoximines such as methionine sulfoximine (MSO) and its derivatives are well studied...

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Detalles Bibliográficos
Autores principales: Ding, Yuxuan, Pedersen, Simon S., Lin, Alex, Qian, Ruoyu, Ball, Zachary T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9728511/
https://www.ncbi.nlm.nih.gov/pubmed/36540816
http://dx.doi.org/10.1039/d2sc04220g