Optimized ACE2 decoys neutralize antibody-resistant SARS-CoV-2 variants through functional receptor mimicry and treat infection in vivo

As severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) evolves to escape natural antibodies, it also loses sensitivity to therapeutic antibody drugs. By contrast, evolution selects for binding to ACE2, the cell-surface receptor required for SARS-CoV-2 infection. Consistent with this, we fin...

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Detalles Bibliográficos
Autores principales: Torchia, James A., Tavares, Alexander H., Carstensen, Laura S., Chen, Da-Yuan, Huang, Jessie, Xiao, Tianshu, Mukherjee, Sonia, Reeves, Patrick M., Tu, Hua, Sluder, Ann E., Chen, Bing, Kotton, Darrell N., Bowen, Richard A., Saeed, Mohsan, Poznansky, Mark C., Freeman, Gordon J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9728973/
https://www.ncbi.nlm.nih.gov/pubmed/36475798
http://dx.doi.org/10.1126/sciadv.abq6527

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9728973/
https://www.ncbi.nlm.nih.gov/pubmed/36475798
http://dx.doi.org/10.1126/sciadv.abq6527

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