Oncogene expression from extrachromosomal DNA is driven by copy number amplification and does not require spatial clustering in glioblastoma stem cells

Extrachromosomal DNA (ecDNA) are frequently observed in human cancers and are responsible for high levels of oncogene expression. In glioblastoma (GBM), ecDNA copy number correlates with poor prognosis. It is hypothesized that their copy number, size, and chromatin accessibility facilitate clusterin...

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Detalles Bibliográficos
Autores principales: Purshouse, Karin, Friman, Elias T, Boyle, Shelagh, Dewari, Pooran Singh, Grant, Vivien, Hamdan, Alhafidz, Morrison, Gillian M, Brennan, Paul M, Beentjes, Sjoerd V, Pollard, Steven M, Bickmore, Wendy A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9728993/
https://www.ncbi.nlm.nih.gov/pubmed/36476408
http://dx.doi.org/10.7554/eLife.80207

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9728993/
https://www.ncbi.nlm.nih.gov/pubmed/36476408
http://dx.doi.org/10.7554/eLife.80207

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