Discovery of a new class of reversible TEA domain transcription factor inhibitors with a novel binding mode

The TEA domain (TEAD) transcription factor forms a transcription co-activation complex with the key downstream effector of the Hippo pathway, YAP/TAZ. TEAD-YAP controls the expression of Hippo-responsive genes involved in cell proliferation, development, and tumorigenesis. Hyperactivation of TEAD-YA...

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Detalles Bibliográficos
Autores principales: Hu, Lu, Sun, Yang, Liu, Shun, Erb, Hannah, Singh, Alka, Mao, Junhao, Luo, Xuelian, Wu, Xu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9728997/
https://www.ncbi.nlm.nih.gov/pubmed/36398861
http://dx.doi.org/10.7554/eLife.80210

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9728997/
https://www.ncbi.nlm.nih.gov/pubmed/36398861
http://dx.doi.org/10.7554/eLife.80210

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