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Gradual differentiation uncoupled from cell cycle exit generates heterogeneity in the epidermal stem cell layer

Highly regenerative tissues continuously produce terminally differentiated cells to replace those that are lost. How they orchestrate the complex transition from undifferentiated stem cells towards post-mitotic, molecularly distinct and often spatially segregated differentiated populations is not we...

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Detalles Bibliográficos
Autores principales: Cockburn, Katie, Annusver, Karl, Gonzalez, David G., Ganesan, Smirthy, May, Dennis P., Mesa, Kailin R., Kawaguchi, Kyogo, Kasper, Maria, Greco, Valentina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9729105/
https://www.ncbi.nlm.nih.gov/pubmed/36357619
http://dx.doi.org/10.1038/s41556-022-01021-8