PLD3 affects axonal spheroids and network defects in Alzheimer’s disease

The precise mechanisms that lead to cognitive decline in Alzheimer’s disease are unknown. Here we identify amyloid-plaque-associated axonal spheroids as prominent contributors to neural network dysfunction. Using intravital calcium and voltage imaging, we show that a mouse model of Alzheimer’s disea...

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Detalles Bibliográficos
Autores principales: Yuan, Peng, Zhang, Mengyang, Tong, Lei, Morse, Thomas M., McDougal, Robert A., Ding, Hui, Chan, Diane, Cai, Yifei, Grutzendler, Jaime
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9729106/
https://www.ncbi.nlm.nih.gov/pubmed/36450991
http://dx.doi.org/10.1038/s41586-022-05491-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9729106/
https://www.ncbi.nlm.nih.gov/pubmed/36450991
http://dx.doi.org/10.1038/s41586-022-05491-6

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