The NALCN channel regulates metastasis and nonmalignant cell dissemination

We identify the sodium leak channel non-selective protein (NALCN) as a key regulator of cancer metastasis and nonmalignant cell dissemination. Among 10,022 human cancers, NALCN loss-of-function mutations were enriched in gastric and colorectal cancers. Deletion of Nalcn from gastric, intestinal or p...

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Detalles Bibliográficos
Autores principales: Rahrmann, Eric P., Shorthouse, David, Jassim, Amir, Hu, Linda P., Ortiz, Mariaestela, Mahler-Araujo, Betania, Vogel, Peter, Paez-Ribes, Marta, Fatemi, Atefeh, Hannon, Gregory J., Iyer, Radhika, Blundon, Jay A., Lourenço, Filipe C., Kay, Jonathan, Nazarian, Rosalynn M., Hall, Benjamin A., Zakharenko, Stanislav S., Winton, Douglas J., Zhu, Liqin, Gilbertson, Richard J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9729110/
https://www.ncbi.nlm.nih.gov/pubmed/36175792
http://dx.doi.org/10.1038/s41588-022-01182-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9729110/
https://www.ncbi.nlm.nih.gov/pubmed/36175792
http://dx.doi.org/10.1038/s41588-022-01182-0

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