Enhancer–promoter interactions and transcription are largely maintained upon acute loss of CTCF, cohesin, WAPL or YY1

It remains unclear why acute depletion of CTCF (CCCTC-binding factor) and cohesin only marginally affects expression of most genes despite substantially perturbing three-dimensional (3D) genome folding at the level of domains and structural loops. To address this conundrum, we used high-resolution M...

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Detalles Bibliográficos
Autores principales: Hsieh, Tsung-Han S., Cattoglio, Claudia, Slobodyanyuk, Elena, Hansen, Anders S., Darzacq, Xavier, Tjian, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9729117/
https://www.ncbi.nlm.nih.gov/pubmed/36471071
http://dx.doi.org/10.1038/s41588-022-01223-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9729117/
https://www.ncbi.nlm.nih.gov/pubmed/36471071
http://dx.doi.org/10.1038/s41588-022-01223-8

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